{"id":618,"date":"2025-12-29T00:04:18","date_gmt":"2025-12-29T00:04:18","guid":{"rendered":"https:\/\/www.zenpeptidesgreymarket.com\/?post_type=product&p=618"},"modified":"2025-12-29T00:04:18","modified_gmt":"2025-12-29T00:04:18","slug":"igf-1lr3","status":"publish","type":"product","link":"https:\/\/www.zenpeptidesgreymarket.com\/?product=igf-1lr3","title":{"rendered":"IGF-1LR3"},"content":{"rendered":"

Enhanced IGF-1 Analog for Potent Growth Factor Research<\/strong><\/h3>\n

IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is an 83-amino acid analog of human IGF-1, comprising the complete 70-amino acid IGF-1 sequence with a 13-amino acid extension peptide at the N-terminus (hence “Long R3”) and an arginine (R) substitution for glutamic acid (E) at position 3. These modifications confer two key research advantages: 1) dramatically reduced affinity for IGF-binding proteins (IGFBPs), increasing bioavailability and potency in experimental systems, and 2) prolonged in-vivo half-life. In research settings, IGF-1 LR3 serves as a powerful tool for investigating the direct effects of potent IGF-1 receptor activation on myoblast differentiation, muscle protein synthesis, chondrocyte and osteoblast activity, neuronal survival, and cellular glucose uptake, with minimal interference from endogenous binding proteins. Supplied as a lyophilized powder, this research-grade growth factor analog is intended strictly for controlled, non-human laboratory studies exploring maximized anabolic signaling, tissue repair, and metabolic regulation.<\/p>\n

Complete Research Kit Contents & Verification<\/strong><\/h3>\n

Each research order provides a complete experimental package designed for growth factor research:<\/p>\n

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    Primary Research Compound:<\/strong>\u00a010 sterile glass vials containing 1mg of lyophilized IGF-1 LR3 peptide powder per vial.\u00a0Note:<\/strong>\u00a01mg is a standard, potent research quantity for this compound.<\/p>\n<\/li>\n

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    Reconstitution Solution:<\/strong>\u00a030ml vial of sterile Bacteriostatic Water (0.9% Benzyl Alcohol) with\u00a00.1M Acetic Acid<\/strong>\u00a0or specified acidic buffer.\u00a0CRITICAL:<\/strong>\u00a0IGF-1 LR3 requires reconstitution in a slightly acidic solution (pH ~4-5) to prevent aggregation and maintain stability. Standard bacteriostatic water may not be suitable alone; an acidic diluent is typically provided or specified.<\/p>\n<\/li>\n

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    Laboratory Administration Tools:<\/strong>\u00a0Pack of sterile 1ml insulin syringes (29G x 1\/2″) for precise measurement and transfer.<\/p>\n<\/li>\n

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    Sterilization Supplies:<\/strong>\u00a0Individually wrapped alcohol prep swabs.<\/p>\n<\/li>\n

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    Research Protocol Documentation:<\/strong><\/p>\n

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      Dosing Schedule:<\/strong>\u00a0Administration protocol for research models, noting the increased potency and longer half-life compared to native IGF-1.<\/p>\n<\/li>\n

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      Usage INSTRUCTIONS (CRITICAL):<\/strong>\u00a0Detailed guide focusing on the unique handling requirements:<\/strong>\u00a0reconstitution in the correct acidic vehicle, avoidance of neutral pH, storage at -20\u00b0C to -80\u00b0C, use of low-protein-binding tubes, and prevention of repeated freeze-thaw cycles to avoid precipitation and loss.<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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      Quality Verification:<\/strong>\u00a0Certificate of Analysis (CoA)<\/strong>\u00a0provided with each batch, detailing:<\/p>\n

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        Purity Analysis (>97% by HPLC – challenging due to size and modifications)<\/p>\n<\/li>\n

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        Structural Verification (Mass Spectrometry):<\/strong><\/p>\n

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          Confirmation of full 83-amino acid sequence<\/p>\n<\/li>\n

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          Verification of N-terminal 13-amino acid extension<\/strong><\/p>\n<\/li>\n

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          Confirmation of Arg\u00b3 substitution (E3R)<\/strong><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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          Molecular Weight: ~9112 Da Confirmed<\/p>\n<\/li>\n

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          Bioactivity\/Potency Assay (Cell proliferation assay, e.g., in MCF-7 cells)<\/p>\n<\/li>\n

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          Sterility Testing<\/p>\n<\/li>\n

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          Endotoxin Levels (<1.0 EU\/\u00b5g –\u00a0stringent due to protein nature<\/strong>)<\/p>\n<\/li>\n

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          Aggregation Analysis (by SEC-HPLC)<\/p>\n<\/li>\n

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          Correct Folding Verification (Disulfide bond pattern)<\/strong><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

          Research Applications & Scientific Utility<\/strong><\/h3>\n

          In a laboratory setting, IGF-1 LR3 enables investigation into potent, unbound IGF-1 receptor signaling. Primary research applications include:<\/p>\n

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            Skeletal Muscle Biology:<\/strong>\u00a0Studying hyper-potent stimulation of myoblast proliferation, differentiation, and muscle fiber hypertrophy in vitro and in muscle injury\/atrophy models.<\/p>\n<\/li>\n

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            Cartilage & Bone Research:<\/strong>\u00a0Investigating effects on chondrocyte and osteoblast activity in models of osteoarthritis, fracture healing, or osteoporosis.<\/p>\n<\/li>\n

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            Metabolic Studies:<\/strong>\u00a0Researching enhanced glucose uptake in myocytes and adipocytes, and its interplay with insulin signaling.<\/p>\n<\/li>\n

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            Tissue Engineering:<\/strong>\u00a0Utilizing as a potent growth factor in bioreactors for cultivating muscle, cartilage, or other IGF-responsive tissues.<\/p>\n<\/li>\n

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            Comparative Studies:<\/strong>\u00a0Serving as a high-potency comparator to native IGF-1 or other IGF variants to isolate the effects of binding protein interaction.<\/p>\n<\/li>\n<\/ul>\n

            Laboratory Handling & Safety Protocol \u2013 EXTREME PRECAUTION<\/strong><\/h3>\n
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              Storage:<\/strong>\u00a0Store unopened vials at\u00a0-80\u00b0C<\/strong>. This is a large, delicate protein. Reconstituted solutions must be aliquoted, stored at -80\u00b0C, and\u00a0never<\/strong>\u00a0refrozen after thawing. Use a single aliquot per experiment.<\/p>\n<\/li>\n

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              Reconstitution:<\/strong>\u00a0Must use the provided acidic diluent (e.g., 0.1M acetic acid).<\/strong>\u00a0Do not use plain bacteriostatic water. Gently swirl to dissolve. Do not vortex. The solution should be clear.<\/p>\n<\/li>\n

            • \n

              Stability:<\/strong>\u00a0The compound is unstable at neutral pH and will precipitate. For in-vivo research, buffer must be adjusted appropriately post-reconstitution for physiological compatibility, which is a complex research step.<\/p>\n<\/li>\n

            • \n

              Laboratory Safety:<\/strong>\u00a0Standard PPE required. Handle as a potent, bioactive growth factor with mitogenic potential. Use appropriate containment.<\/p>\n<\/li>\n<\/ul>\n

              \u26a0\ufe0f Critical Compliance & Intended Use Disclaimer:<\/strong><\/p>\n

              THIS PRODUCT IS SOLD FOR RESEARCH USE ONLY (RUO). NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.<\/strong><\/p>\n

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              1. \n

                Intended Use:<\/strong>\u00a0IGF-1 LR3 is supplied as a potent biochemical reagent for laboratory research purposes only. It is intended for use by qualified researchers in controlled non-human settings. The “dosing schedule” is for research models only.<\/p>\n<\/li>\n

              2. \n

                Not for Human Consumption:<\/strong>\u00a0Under\u00a0ABSOLUTELY NO CIRCUMSTANCES<\/strong>\u00a0is this product intended for human or animal administration. It is a potent growth factor with\u00a0mitogenic and potentially carcinogenic risks<\/strong>. It is not a performance-enhancing or muscle-building drug.<\/p>\n<\/li>\n

              3. \n

                Regulatory Status:<\/strong>\u00a0This product has not been evaluated or approved by any health authority. It is an investigational research compound with significant known risks.<\/p>\n<\/li>\n

              4. \n

                Handling Risk:<\/strong>\u00a0The researcher assumes all risk for handling this biologically active protein, including potential self-exposure risks.<\/p>\n<\/li>\n

              5. \n

                Researcher Responsibility:<\/strong>\u00a0The purchaser is solely responsible for compliance with all laws and biosafety regulations, particularly those governing the use of potent growth factors.<\/p>\n<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

                YOUR ORDER COMES WITH;<\/strong><\/p>\n

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                  10 VIALS x 1mg<\/strong>\u00a0of IGF-1 LR3 Research Peptide<\/p>\n<\/li>\n

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                  FREE:<\/strong>\u00a0Bacteriostatic Water (30ml), Sterile Syringes (1ml, 29G), and Alcohol Swabs<\/p>\n<\/li>\n

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                  DOSING SCHEDULE:<\/strong>\u00a0Comprehensive laboratory administration protocol for research models<\/p>\n<\/li>\n

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                  USAGE INSTRUCTIONS:<\/strong>\u00a0Detailed reconstitution guide, stability parameters, and handling procedures for this potent growth factor<\/p>\n<\/li>\n

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                  A COPY OF LAB RESULTS:<\/strong>\u00a0Certificate of Analysis (CoA) confirming purity, sequence, and sterility<\/p>\n<\/li>\n<\/ul>\n

                  IGF-1 LR3 is a modified analog of Insulin-like Growth Factor-1 with an extended R3 chain and altered sequence for reduced binding protein affinity, supplied for research into potentiated anabolic signaling, cellular proliferation, and glucose metabolism. This complete research kit includes all necessary components for standardized experimental studies in growth factor biology.<\/p>\n","protected":false},"featured_media":512,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[24],"product_tag":[],"class_list":["post-618","product","type-product","status-publish","has-post-thumbnail","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-variable"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.zenpeptidesgreymarket.com\/index.php?rest_route=\/wp\/v2\/product\/618","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.zenpeptidesgreymarket.com\/index.php?rest_route=\/wp\/v2\/product"}],"about":[{"href":"https:\/\/www.zenpeptidesgreymarket.com\/index.php?rest_route=\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/www.zenpeptidesgreymarket.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=618"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.zenpeptidesgreymarket.com\/index.php?rest_route=\/wp\/v2\/media\/512"}],"wp:attachment":[{"href":"https:\/\/www.zenpeptidesgreymarket.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=618"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/www.zenpeptidesgreymarket.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_brand&post=618"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/www.zenpeptidesgreymarket.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_cat&post=618"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/www.zenpeptidesgreymarket.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_tag&post=618"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}