{"id":664,"date":"2025-12-29T01:11:00","date_gmt":"2025-12-29T01:11:00","guid":{"rendered":"https:\/\/www.zenpeptidesgreymarket.com\/?post_type=product&p=664"},"modified":"2025-12-29T01:20:40","modified_gmt":"2025-12-29T01:20:40","slug":"kpv","status":"publish","type":"product","link":"https:\/\/www.zenpeptidesgreymarket.com\/?product=kpv","title":{"rendered":"KPV"},"content":{"rendered":"

\u03b1-MSH-derived Tripeptide for Localized Anti-Inflammatory Research<\/strong><\/h3>\n

KPV (sequence: H-Lys-Pro-Val-OH) is a synthetic tripeptide representing the C-terminal 11-13 fragment of the endogenous neuroimmunomodulatory hormone \u03b1-Melanocyte-Stimulating Hormone (\u03b1-MSH). While full-length \u03b1-MSH exerts broad anti-inflammatory and immunomodulatory effects primarily through activation of melanocortin receptors (MC1R and MC3-5R), the KPV fragment appears to act through distinct, receptor-independent mechanisms in research models. Its small size and specific charge distribution allow it to interact directly with cellular targets involved in inflammatory signaling. In laboratory settings, KPV serves as a focused tool for investigating localized anti-inflammatory pathways, particularly in mucosal and dermal tissues. Research suggests it may inhibit NF-\u03baB translocation, reduce pro-inflammatory cytokine production (e.g., TNF-\u03b1, IL-1\u03b2, IL-6), and enhance the expression of anti-inflammatory mediators. Supplied as a lyophilized powder in a larger 50mg quantity suitable for topical\/oral formulation research, this peptide is intended strictly for controlled, non-human laboratory studies exploring targeted, localized intervention in inflammatory conditions.<\/p>\n

Complete Research Kit Contents & Verification<\/strong><\/h3>\n

Each research order provides a complete experimental package designed for inflammation and formulation research:<\/p>\n

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    Primary Research Compound:<\/strong>\u00a010 sterile glass vials containing 50mg of lyophilized KPV peptide powder per vial.\u00a0Note:<\/strong>\u00a0The 50mg size is appropriate for topical\/oral formulation studies requiring higher peptide mass.<\/p>\n<\/li>\n

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    Reconstitution Solution:<\/strong>\u00a030ml vial of sterile Bacteriostatic Water (0.9% Benzyl Alcohol) or phosphate-buffered saline for experimental use.<\/p>\n<\/li>\n

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    Laboratory Administration Tools:<\/strong>\u00a0Pack of sterile 1ml insulin syringes (29G x 1\/2″) for precise measurement and formulation.<\/p>\n<\/li>\n

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    Sterilization Supplies:<\/strong>\u00a0Individually wrapped alcohol prep swabs.<\/p>\n<\/li>\n

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    Research Protocol Documentation:<\/strong><\/p>\n

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      Dosing Schedule\/Formulation Guide:<\/strong>\u00a0Protocol for administering KPV in research models, with emphasis on\u00a0local\/topical\/oral administration<\/strong>\u00a0(e.g., enema models for colitis, topical application for dermatitis, oral gavage for gut barrier studies). Includes typical research concentrations.<\/p>\n<\/li>\n

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      Usage Instructions:<\/strong>\u00a0Comprehensive guide covering reconstitution, stability in various vehicles (creams, gels, solutions for gavage), storage conditions (-20\u00b0C recommended), and handling safety.<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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      Quality Verification:<\/strong>\u00a0Certificate of Analysis (CoA)<\/strong>\u00a0provided with each batch, detailing:<\/p>\n

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        Purity Analysis (>98% by HPLC)<\/p>\n<\/li>\n

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        Amino Acid Sequence Verification (Mass Spectrometry) – Critical for this short sequence.<\/p>\n<\/li>\n

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        Molecular Weight: 342.4 Da Confirmed<\/p>\n<\/li>\n

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        Sterility Testing Results (Optional but recommended for in-vivo mucosal studies)<\/p>\n<\/li>\n

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        Endotoxin Levels (<10 EU\/mg) –\u00a0Important for inflammation research to avoid confounding results.<\/strong><\/p>\n<\/li>\n

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        Residual Solvent Analysis<\/p>\n<\/li>\n

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        Net Peptide Content<\/p>\n<\/li>\n

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        Chiral Purity<\/strong>\u00a0(L-amino acids)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

        Research Applications & Scientific Utility<\/strong><\/h3>\n

        In a laboratory setting, KPV enables investigation into a minimalist, localized approach to inflammation. Primary research applications include:<\/p>\n

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          Inflammatory Bowel Disease (IBD) Models:<\/strong>\u00a0Researching effects in chemical-induced colitis models (DSS, TNBS), measuring disease activity index, colon histology, myeloperoxidase activity, and cytokine profiles in gut tissue.<\/p>\n<\/li>\n

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          Dermatitis & Skin Inflammation:<\/strong>\u00a0Studying topical efficacy in models of contact dermatitis, psoriasis, or atopic dermatitis, assessing ear thickness, cytokine levels, and histological changes.<\/p>\n<\/li>\n

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          Gut Barrier Function:<\/strong>\u00a0Investigating protection against barrier disruption and “leaky gut” in models of intestinal inflammation or infection.<\/p>\n<\/li>\n

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          Mechanistic Studies:<\/strong>\u00a0Exploring its direct interaction with inflammatory signaling pathways (e.g., inhibition of I\u03baB\u03b1 degradation, NF-\u03baB nuclear translocation) in cell culture models of macrophages or epithelial cells.<\/p>\n<\/li>\n

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          Comparative Studies:<\/strong>\u00a0Serving as a minimalist counterpart to full-length \u03b1-MSH or other anti-inflammatory peptides (e.g., BPC-157) to dissect receptor-dependent vs. independent actions.<\/p>\n<\/li>\n<\/ul>\n

          Laboratory Handling & Safety Protocol<\/strong><\/h3>\n
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            Storage:<\/strong>\u00a0Store unopened lyophilized peptide vials at -20\u00b0C or below. The tripeptide is chemically stable. Reconstituted solutions for in-vivo use should be aliquoted and stored at -20\u00b0C.<\/p>\n<\/li>\n

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            Reconstitution:<\/strong>\u00a0Perform under sterile conditions if for in-vivo use. The peptide is highly soluble. Swirl gently.<\/p>\n<\/li>\n

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            Laboratory Safety:<\/strong>\u00a0Standard PPE is required.<\/p>\n<\/li>\n

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            Formulation for Local Delivery:<\/strong>\u00a0Researchers should have expertise in formulating for specific local routes (rectal, topical, oral) to ensure proper delivery and stability in the research model.<\/p>\n<\/li>\n<\/ul>\n

            \u26a0\ufe0f Critical Compliance & Intended Use Disclaimer:<\/strong><\/p>\n

            THIS PRODUCT IS SOLD FOR RESEARCH USE ONLY (RUO). NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.<\/strong><\/p>\n

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            1. \n

              Intended Use:<\/strong>\u00a0KPV is supplied as a biochemical reagent for laboratory research purposes only. It is intended for use by qualified researchers in controlled settings studying immunology and inflammatory mechanisms. The “dosing schedule” refers to research model protocols only.<\/p>\n<\/li>\n

            2. \n

              Not for Human Consumption:<\/strong>\u00a0Under no circumstances is this product intended for human or animal therapeutic use. It is not a treatment for IBD, colitis, dermatitis, or any inflammatory condition. The provided supplies are for laboratory formulation and measurement.<\/p>\n<\/li>\n

            3. \n

              Regulatory Status:<\/strong>\u00a0This product has not been evaluated or approved by the FDA or any health authority for any use.<\/p>\n<\/li>\n

            4. \n

              Local vs. Systemic:<\/strong>\u00a0The research focus of KPV is on\u00a0localized effects<\/strong>. This should be emphasized to differentiate it from systemic anti-inflammatory drugs.<\/p>\n<\/li>\n

            5. \n

              Researcher Responsibility:<\/strong>\u00a0The purchaser assumes full responsibility for compliance with all regulations and for ensuring this compound is used only for legitimate, non-human research<\/p>\n<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

              YOUR ORDER COMES WITH;<\/strong><\/p>\n

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                10 VIALS x 50mg<\/strong>\u00a0of KPV (Lys-Pro-Val) Research Peptide<\/p>\n<\/li>\n

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                FREE:<\/strong>\u00a0Bacteriostatic Water (30ml), Sterile Syringes (1ml, 29G), and Alcohol Swabs<\/p>\n<\/li>\n

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                DOSING SCHETULE:<\/strong>\u00a0Comprehensive laboratory administration protocol for research models<\/p>\n<\/li>\n

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                USAGE INSTRUCTIONS:<\/strong>\u00a0Detailed reconstitution guide, stability parameters, and handling procedures<\/p>\n<\/li>\n

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                A COPY OF LAB RESULTS:<\/strong>\u00a0Certificate of Analysis (CoA) confirming purity, sequence, and sterility<\/p>\n<\/li>\n<\/ul>\n

                KPV is the C-terminal tripeptide fragment (Lys-Pro-Val) of \u03b1-Melanocyte-Stimulating Hormone (\u03b1-MSH), supplied for research into localized anti-inflammatory effects, cytokine modulation, and intestinal barrier protection without systemic melanocortin receptor activation. This complete research kit includes all necessary components for standardized experimental studies in immunology and inflammation.<\/p>\n","protected":false},"featured_media":667,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[24],"product_tag":[],"class_list":["post-664","product","type-product","status-publish","has-post-thumbnail","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-variable"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.zenpeptidesgreymarket.com\/index.php?rest_route=\/wp\/v2\/product\/664","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.zenpeptidesgreymarket.com\/index.php?rest_route=\/wp\/v2\/product"}],"about":[{"href":"https:\/\/www.zenpeptidesgreymarket.com\/index.php?rest_route=\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/www.zenpeptidesgreymarket.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=664"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.zenpeptidesgreymarket.com\/index.php?rest_route=\/wp\/v2\/media\/667"}],"wp:attachment":[{"href":"https:\/\/www.zenpeptidesgreymarket.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=664"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/www.zenpeptidesgreymarket.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_brand&post=664"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/www.zenpeptidesgreymarket.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_cat&post=664"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/www.zenpeptidesgreymarket.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_tag&post=664"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}