Cagrilitide 5mg

Long-Acting Amylin Analogue for Appetite & Metabolic Research

Cagrilintide (formerly AM833) is a synthetic, acylated peptide analogue of the pancreatic hormone amylin, engineered with a fatty acid side chain to confer extended duration of action through albumin binding. Amylin is a 37-amino acid peptide co-secreted with insulin by pancreatic beta-cells that contributes to glycemic control by suppressing glucagon secretion, slowing gastric emptying, and promoting satiety. As a research tool, Cagrilintide’s modified structure allows scientists to investigate the sustained activation of amylin receptors in the brainstem and other areas, providing insights into prolonged appetite suppression, weight management, and potential synergistic effects with other metabolic hormones like GLP-1. Supplied as an acetate salt, this lyophilized peptide is intended strictly for controlled, non-human laboratory research into the pharmacology of long-acting satiety signals and combination metabolic therapies.

Complete Research Kit Contents & Verification

Each research order provides a complete experimental package designed for advanced metabolic research:

• Primary Research Compound: 10 sterile glass vials containing 5mg of lyophilized Cagrilintide Acetate peptide powder per vial.

• Reconstitution Solution: 30ml vial of sterile Bacteriostatic Water (0.9% Benzyl Alcohol), essential for creating stable peptide solutions for experimental use. Note: The acylated nature may require gentle warming or extended mixing for complete reconstitution.

• Laboratory Administration Tools: Pack of sterile 1ml insulin syringes (29G x 1/2″) for precise measurement and transfer.

• Sterilization Supplies: Individually wrapped alcohol prep swabs to maintain aseptic technique.

• Research Protocol Documentation:

  • Dosing Schedule: Standardized administration protocol for research models, reflecting the compound’s long half-life (suitable for less frequent dosing in chronic studies).

  • Usage Instructions: Comprehensive guide covering specific reconstitution considerations for acylated peptides, storage conditions (-20°C to -80°C recommended), handling safety, and experimental design for chronic weight management models.

• Quality Verification: Certificate of Analysis (CoA) provided with each batch, detailing:

  • Purity Analysis (>97% by HPLC/UPLC – complexity due to acylation)

  • Peptide Sequence & Acylation Site Verification (Mass Spectrometry)

  • Molecular Weight Confirmation (Approx. ~4.4 kDa – varies based on fatty acid)

  • Sterility Testing Results

  • Endotoxin Levels (<10 EU/mg)

  • Free Fatty Acid Content & Acylation Efficiency

  • Residual Solvent Analysis

  • Aggregation Assessment (SEC-HPLC for large, modified peptides)

Research Applications & Scientific Utility

In a laboratory setting, Cagrilintide enables investigation into sustained amylin receptor activation. Primary research applications include studying mechanisms of prolonged appetite suppression and satiety signaling in central nervous system models, researching effects on gastric emptying and nutrient absorption over extended periods, investigating combination therapy with GLP-1 receptor agonists (e.g., semaglutide) for potential synergistic weight loss effects, exploring the role of amylin in glycemic control independent of and alongside insulin, and modeling long-term weight management and obesity treatment in preclinical studies. Its extended pharmacokinetic profile makes it particularly useful for research designs requiring sustained receptor engagement without frequent dosing.

Laboratory Handling & Safety Protocol

• Storage: Store unopened lyophilized peptide vials at -20°C or preferably -80°C due to the complex, acylated structure. Avoid repeated freeze-thaw cycles of reconstituted solutions; aliquot upon reconstitution.

• Reconstitution: May require patience. Add bacteriostatic water slowly along the vial wall. Allow to sit for 15-30 minutes, then swirl gently. Do not vortex aggressively. Slight warming to room temperature before reconstitution can aid solubility.

• Laboratory Safety: Standard personal protective equipment (PPE) including lab coat, nitrile gloves, and safety glasses must be worn. Handle as a potent, long-acting biological research compound.

• Experimental Design: Researchers should account for the long half-life (potentially several days in models) when designing dosing intervals, washout periods, and control experiments.

⚠️ Critical Compliance & Intended Use Disclaimer:

THIS PRODUCT IS SOLD FOR RESEARCH USE ONLY (RUO). NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

1. Intended Use: Cagrilintide is supplied as a novel biochemical reagent for laboratory research purposes only. It is intended for use by qualified researchers in controlled settings studying metabolic pharmacology and obesity research. The included “dosing schedule” refers to standardized research model administration protocols only.

2. Not for Human Consumption: Under no circumstances is this product intended for administration to humans or animals. It is an investigational compound, not a drug or weight loss supplement. Its safety profile in humans is under investigation. The provided supplies are for laboratory use only.

3. Regulatory Status: This product is an investigational new drug candidate. It has not been approved by the FDA or any global health authority for any use. It is supplied solely to facilitate basic and translational research.

4. Intellectual Property Notice: Cagrilintide is an investigational compound of Novo Nordisk A/S. This supply is for non-commercial research use only in accordance with applicable research use exemptions.

5. Researcher Responsibility: It is the sole responsibility of the purchasing individual/institution to ensure compliance with all regulations and to use this compound strictly for legitimate, non-human research within approved ethical guidelines.