MOTS-c 10mg

Mitochondrial-Encoded Signaling Peptide for Metabolic & Aging Research

MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA-c) is a pioneering 16-amino acid peptide (sequence: MRWQEMGYIFYPRKLR) encoded within the mitochondrial 12S rRNA gene, representing a fascinating class of mitochondrial-derived peptides (MDPs) or “mitokines.” This discovery established a novel mechanism of mitochondrial-nuclear communication, where the mitochondrion itself produces signaling peptides that translocate to the nucleus to regulate gene expression in response to metabolic stress. In research settings, MOTS-c serves as a vital tool for investigating its role in enhancing insulin sensitivity, promoting glucose uptake, regulating metabolic homeostasis, and mimicking certain adaptive exercise responses. Supplied as a lyophilized powder, this research-grade peptide is intended strictly for controlled, non-human laboratory studies exploring the frontiers of mitochondrial signaling, aging metabolism, and the development of potential exercise mimetics.

Complete Research Kit Contents & Verification

Each research order provides a complete experimental package designed for advanced mitochondrial and metabolic research:

• Primary Research Compound: 10 sterile glass vials containing 10mg of lyophilized MOTS-c peptide powder per vial.

• Reconstitution Solution: 30ml vial of sterile Bacteriostatic Water (0.9% Benzyl Alcohol) for experimental use.

• Laboratory Administration Tools: Pack of sterile 1ml insulin syringes (29G x 1/2″) for precise measurement and transfer.

• Sterilization Supplies: Individually wrapped alcohol prep swabs.

• Research Protocol Documentation:

  • Dosing Schedule: Standardized administration protocol for research models, based on emerging preclinical data for this novel peptide.

  • Usage Instructions: Comprehensive guide covering reconstitution, storage conditions (-20°C to -80°C recommended), handling safety, and specific considerations for studying mitochondrial-derived peptides (e.g., cellular localization assays).

• Quality Verification: Certificate of Analysis (CoA) provided with each batch, detailing:

  • Purity Analysis (>98% by HPLC)

  • Amino Acid Sequence Verification (Mass Spectrometry) – Critical for confirming the unique mitochondrial sequence.

  • Molecular Weight: 2174.6 Da Confirmed

  • Sterility Testing Results

  • Endotoxin Levels (<10 EU/mg)

  • Residual Solvent Analysis

  • Peptide Mapping for Identity

  • Mitochondrial Origin Verification Note: While synthesized, the CoA confirms the sequence is identical to the human mitochondrial-encoded MOTS-c.

Research Applications & Scientific Utility

In a laboratory setting, MOTS-c enables innovative research at the intersection of metabolism, aging, and cellular signaling. Primary research applications include:

• Mitochondrial-Nuclear Crosstalk: Studying the translocation of MOTS-c to the nucleus and its regulation of nuclear-encoded genes involved in stress response and metabolism (e.g., upregulation of AMPK pathway).

• Exercise Mimetics: Researching its ability to replicate aspects of exercise adaptation, such as improved metabolic flexibility and insulin sensitivity, in sedentary or metabolic disease models.

• Aging Metabolism: Investigating the role of MOTS-c in age-related metabolic decline and testing its potential to restore youthful metabolic parameters.

• Obesity & Diabetes Models: Exploring therapeutic mechanisms in diet-induced obesity, insulin resistance, and non-alcoholic fatty liver disease (NAFLD) models.

• Mitokine Biology: Using MOTS-c as a prototype to study the broader class of mitochondrial-derived peptides and their signaling functions.

Laboratory Handling & Safety Protocol

• Storage: Store unopened lyophilized peptide vials at -20°C or, for maximum long-term stability of this research peptide, at -80°C. Reconstituted solutions should be aliquoted and stored at -80°C.

• Reconstitution: Perform under sterile conditions using the provided bacteriostatic water. Swirl gently to dissolve.

• Laboratory Safety: Standard PPE (lab coat, gloves, safety glasses) is required. As a novel biological signaling molecule, handle with appropriate caution.

⚠️ Critical Compliance & Intended Use Disclaimer:

THIS PRODUCT IS SOLD FOR RESEARCH USE ONLY (RUO). NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

1. Intended Use: MOTS-c is supplied as a novel biochemical reagent for laboratory research purposes only. It is intended for use by qualified researchers in controlled settings studying mitochondrial biology and metabolic signaling. The included “dosing schedule” refers to experimental research model protocols only.

2. Not for Human Consumption: Under no circumstances is this product intended for administration to humans or animals. It is an investigational research compound, not an exercise mimetic, weight loss, or anti-aging product for human use. The provided supplies are for laboratory use only.

3. Regulatory Status: This product is an investigational compound that has not been approved for any use by the FDA or any global health authority. It represents early-stage, cutting-edge research.

4. Novel Research Area: MOTS-c is a recently discovered peptide. Its full range of biological activities and long-term effects are not yet fully characterized, even in preclinical models. Researchers assume responsibility for appropriate experimental design.

5. Researcher Responsibility: It is the sole responsibility of the purchasing institution to ensure compliance with all regulations and to use this peptide strictly for legitimate, non-human research.