P21 (PO21) 5mg

Cerebrolysin-Derived Peptide for Neurotrophic & Cognitive Research

P21 is a synthetic peptide comprising 11 amino acids (Leu-Val-Gly-Arg-Thr-Leu-Arg-Gly-Leu-Pro-Tyr) that corresponds to an active subfragment identified within the complex porcine brain-derived peptide preparation, Cerebrolysin. This peptide was designed to isolate and study a specific component responsible for some of the neurotrophic and neuroprotective effects observed with the parent compound. In research settings, P21 serves as a focused tool for investigating mechanisms of neuronal survival, neurite outgrowth, synaptogenesis, and cognitive enhancement without the complexity of the full multi-peptide mixture. It is believed to act through modulation of neurotrophic factor expression (particularly BDNF – Brain-Derived Neurotrophic Factor) and downstream signaling pathways like PI3K/Akt and MAPK/ERK. Supplied as a lyophilized powder, this research-grade peptide is intended strictly for controlled, non-human laboratory studies exploring targeted approaches to neurodegenerative diseases, cognitive disorders, and brain repair mechanisms.

Complete Research Kit Contents & Verification

Each research order provides a complete experimental package designed for neuroscience research:

• Primary Research Compound: 10 sterile glass vials containing 5mg of lyophilized P21 peptide powder per vial.

• Reconstitution Solution: 30ml vial of sterile Bacteriostatic Water (0.9% Benzyl Alcohol) for experimental use.

• Laboratory Administration Tools: Pack of sterile 1ml insulin syringes (29G x 1/2″) for precise measurement and transfer.

• Sterilization Supplies: Individually wrapped alcohol prep swabs.

• Research Protocol Documentation:

  • Dosing Schedule: Standardized administration protocol for research models focusing on neuroprotection, cognitive behavioral studies, and neuronal cell culture work.

  • Usage INSTRUCTIONS: Comprehensive guide covering reconstitution, storage conditions (-20°C recommended), handling safety, and considerations for research involving the central nervous system (e.g., blood-brain barrier penetration studies, ICV administration protocols).

• Quality Verification: Certificate of Analysis (CoA) provided with each batch, detailing:

  • Purity Analysis (>98% by HPLC)

  • Amino Acid Sequence Verification (Mass Spectrometry) – Critical for confirming the specific 11-mer sequence.

  • Molecular Weight: 1244.5 Da Confirmed

  • Sterility Testing Results

  • Endotoxin Levels (<10 EU/mg) – Particularly important for neuroscience research.

  • Residual Solvent Analysis

  • Net Peptide Content

Research Applications & Scientific Utility

In a laboratory setting, P21 enables targeted investigation into a specific neurotrophic pathway. Primary research applications include:

• Neurogenesis & Neurite Outgrowth: Studying the promotion of neuronal stem cell differentiation and neurite extension in primary neuronal cultures or neural stem cell models.

• Synaptic Plasticity Research: Investigating long-term potentiation (LTP) enhancement, synaptogenesis, and BDNF expression in brain slice or in-vivo electrophysiology models.

• Neurodegenerative Disease Models: Researching potential protective or restorative effects in models of Alzheimer’s disease (e.g., amyloid-beta toxicity, tauopathy), Parkinson’s disease, or traumatic brain injury.

• Cognitive & Behavioral Studies: Examining effects on learning, memory, and executive function in rodent behavioral paradigms (Morris water maze, radial arm maze, etc.).

• Mechanistic Studies: Serving as a tool to dissect the specific signaling pathways (PI3K/Akt, CREB, etc.) activated by this Cerebrolysin fragment, distinct from other neurotrophic factors.

Laboratory Handling & Safety Protocol

• Storage: Store unopened lyophilized peptide vials at -20°C or below. Reconstituted solutions should be aliquoted and stored at -20°C.

• Reconstitution: Perform under sterile conditions. The peptide is readily soluble. Swirl gently.

• Laboratory Safety: Standard PPE is required. For in-vivo neuroscience research, all institutional IACUC and biosafety guidelines must be followed meticulously.

• Neurospecific Considerations: Researchers should be aware of administration routes (intraperitoneal vs. intracerebroventricular) and their implications for dose and bioavailability in brain tissue.

⚠️ Critical Compliance & Intended Use Disclaimer:

THIS PRODUCT IS SOLD FOR RESEARCH USE ONLY (RUO). NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

1. Intended Use: P21 is supplied as a biochemical reagent for laboratory research purposes only. It is intended for use by qualified neuroscience researchers in controlled non-human settings. The “dosing schedule” is for research models only.

2. Not for Human Consumption: Under no circumstances is this product intended for administration to humans. It is not a nootropic, cognitive enhancer, or treatment for Alzheimer’s or any brain disorder. The provided supplies are for laboratory use.

3. Regulatory Status: This product has not been evaluated or approved by the FDA or any health authority for any use. Cerebrolysin is approved in some countries, but P21 is a distinct, investigational research fragment.

4. Relation to Cerebrolysin: P21 is a single synthetic peptide inspired by Cerebrolysin. It is NOT Cerebrolysin, does not contain the full spectrum of Cerebrolysin’s components, and its effects may differ.

5. Researcher Responsibility: The purchaser assumes full responsibility for compliance with all laws and ethical guidelines, especially those governing animal research in neuroscience.