Selank

Synthetic Nootropic & Anxiolytic Peptide Analog for Neuropsychiatric Research

Selank (sequence: H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH) is a synthetic 7-amino acid peptide developed as an analog of the endogenous immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg). With the addition of a C-terminal Pro-Gly-Pro tripeptide, Selank was designed to possess enhanced metabolic stability and central nervous system activity compared to its parent compound. In research settings, Selank serves as a tool for investigating the modulation of anxiety-like behaviors, cognitive processes, and the intricate interplay between the immune and nervous systems. Its proposed mechanisms, based on preclinical research, include influencing the metabolism of serotonin and other monoamines, modulating GABAergic transmission, increasing brain-derived neurotrophic factor (BDNF) levels, and affecting the expression of genes involved in stress response. Supplied as an acetate salt, this lyophilized peptide is intended strictly for controlled, non-human laboratory studies exploring novel pathways in neuropsychopharmacology and behavioral neuroscience.

Complete Research Kit Contents & Verification

Each research order provides a complete experimental package designed for behavioral and neurochemical research:

• Primary Research Compound: 10 sterile glass vials containing 5mg of lyophilized Selank Acetate peptide powder per vial.

• Reconstitution Solution: 30ml vial of sterile Bacteriostatic Water (0.9% Benzyl Alcohol) for experimental use.

• Laboratory Administration Tools: Pack of sterile 1ml insulin syringes (29G x 1/2″) for precise measurement and transfer in accordance with research protocols.

• Sterilization Supplies: Individually wrapped alcohol prep swabs to maintain aseptic technique.

• Research Protocol Documentation:

  • Dosing Schedule: Standardized administration protocol for research models focusing on behavioral tests (elevated plus maze, open field test, forced swim test), memory paradigms (Morris water maze, passive avoidance), and neurochemical sampling.

  • Usage Instructions: Comprehensive guide covering reconstitution math, storage conditions (-20°C recommended), handling safety, and considerations for administration routes common in neuroscience (intraperitoneal, subcutaneous, intranasal in animal models).

• Quality Verification: Certificate of Analysis (CoA) provided with each batch, detailing:

  • Purity Analysis (>98% by HPLC)

  • Amino Acid Sequence Verification (Mass Spectrometry) – Critical for confirming the specific 7-mer sequence.

  • Molecular Weight: 751.9 Da (Free Acid) / ~811 Da (Acetate Salt, approximate)

  • Sterility Testing Results

  • Endotoxin Levels (<10 EU/mg) – Stringent requirement for peptides used in behavioral research.

  • Residual Solvent Analysis

  • Salt Form Confirmation (Acetate)

  • Net Peptide Content

Research Applications & Scientific Utility

In a laboratory setting, Selank enables investigation into peptide-mediated modulation of behavior and neurochemistry. Primary research applications include:

• Anxiety & Depression Models: Studying effects in validated behavioral models of anxiety (e.g., elevated plus maze, light-dark box) and depression (e.g., forced swim test, tail suspension test), often in comparison to standard anxiolytic/antidepressant drugs.

• Cognitive & Memory Research: Investigating potential nootropic effects on learning, memory consolidation, and retrieval in fear conditioning, Morris water maze, or novel object recognition tasks.

• Neurochemical Studies: Researching changes in neurotransmitter levels (serotonin, dopamine, GABA), their metabolites, and related enzyme activities (monoamine oxidase) in specific brain regions post-administration.

• Stress Response Research: Exploring modulation of the hypothalamic-pituitary-adrenal (HPA) axis and expression of stress-related genes (e.g., corticotropin-releasing factor, BDNF).

• Immune-Neuro Interaction: Serving as a tool to study the communication between the immune system (via its tuftsin ancestry) and brain function/behavior.

Laboratory Handling & Safety Protocol

• Storage: Store unopened lyophilized peptide vials at -20°C or below. Reconstituted solutions should be aliquoted and stored at -20°C and used within a reasonable timeframe.

• Reconstitution: Must be performed under sterile laboratory conditions using the provided bacteriostatic water. The peptide dissolves readily. Swirl gently to dissolve.

• Laboratory Safety: Standard personal protective equipment (PPE) is required. For in-vivo behavioral research, all institutional IACUC guidelines must be followed meticulously.

• Behavioral Testing: Researchers should be blinded to treatment conditions during behavioral scoring to prevent bias.

⚠️ Critical Compliance & Intended Use Disclaimer:

THIS PRODUCT IS SOLD FOR RESEARCH USE ONLY (RUO). NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

1. Intended Use: Selank is supplied as a biochemical reagent for laboratory research purposes only. It is intended for use by qualified neuroscience researchers in controlled non-human settings. The “dosing schedule” is for research models only.

2. Not for Human Consumption: Under no circumstances is this product intended for administration to humans. It is not a nootropic, anti-anxiety supplement, or cognitive enhancer for human use. The provided supplies are for laboratory use only.

3. Regulatory Status: This product has not been evaluated or approved by the FDA or any other health authority for the diagnosis, treatment, or prevention of any psychiatric or neurological condition.

4. Regional Note: While Selank is approved as a prescription drug in Russia, THIS SPECIFIC PRODUCT IS NOT THAT DRUG and is not manufactured, packaged, or intended for human therapeutic use.

5. Researcher Responsibility: The purchaser assumes full responsibility for compliance with all laws and ethical guidelines governing animal research in neuroscience and psychology.