Semax

Synthetic Neuroprotective & Nootropic Peptide for CNS Research

Semax (sequence: H-Met-Glu-His-Phe-Pro-Gly-Pro-OH) is a synthetic 7-amino acid peptide developed from the adrenocorticotropic hormone fragment ACTH(4-10) with the addition of a C-terminal Pro-Gly-Pro tripeptide to enhance metabolic stability and central nervous system activity. Unlike its parent molecule, Semax lacks corticotropic activity while exhibiting potent neuroprotective, nootropic, and neurotrophic properties in preclinical models. In research settings, Semax serves as a valuable tool for investigating mechanisms of cognitive enhancement, neuronal survival under stress, and neuroplasticity. Its proposed research mechanisms, based on animal and in-vitro studies, include upregulation of brain-derived neurotrophic factor (BDNF) and its receptor TrkB, modulation of neurotransmitter systems (particularly dopamine and serotonin), enhancement of antioxidant defense enzymes, and influence on gene expression related to neuronal growth and stress adaptation. Supplied as an acetate salt, this lyophilized peptide is intended strictly for controlled, non-human laboratory studies exploring novel interventions for neurological disorders and cognitive function.

Complete Research Kit Contents & Verification

Each research order provides a complete experimental package designed for advanced neuroscience research:

• Primary Research Compound: 10 sterile glass vials containing 5mg of lyophilized Semax Acetate peptide powder per vial.

• Reconstitution Solution: 30ml vial of sterile Bacteriostatic Water (0.9% Benzyl Alcohol) for experimental use.

• Laboratory Administration Tools: Pack of sterile 1ml insulin syringes (29G x 1/2″) for precise measurement and transfer.

• Sterilization Supplies: Individually wrapped alcohol prep swabs.

• Research Protocol Documentation:

  • Dosing Schedule: Standardized administration protocol for research models focusing on cerebral ischemia/stroke, cognitive behavioral tests, neurochemical assays, and neuronal cell culture studies.

  • Usage Instructions: Comprehensive guide covering reconstitution math, storage conditions (-20°C recommended), handling safety, and specific considerations for neuroscience research (e.g., intranasal administration protocols in rodent models, blood-brain barrier studies).

• Quality Verification: Certificate of Analysis (CoA) provided with each batch, detailing:

  • Purity Analysis (>98% by HPLC)

  • Amino Acid Sequence Verification (Mass Spectrometry) – Critical for confirming the specific 7-mer sequence and the N-terminal methionine (susceptible to oxidation).

  • Molecular Weight: 813.9 Da (Free Acid) / ~873 Da (Acetate Salt, approximate)

  • Oxidation Check (for methionine) – Important for activity.

  • Sterility Testing Results

  • Endotoxin Levels (<10 EU/mg) – Essential for in-vivo CNS research.

  • Residual Solvent Analysis

  • Salt Form Confirmation (Acetate)

  • Net Peptide Content

Research Applications & Scientific Utility

In a laboratory setting, Semax enables investigation into multifaceted neuroprotective and cognitive mechanisms. Primary research applications include:

• Cerebral Ischemia & Stroke Models: Researching neuroprotective effects in middle cerebral artery occlusion (MCAO) models, measuring infarct volume, neurological deficit scores, and markers of apoptosis.

• Cognitive & Memory Studies: Investigating nootropic effects in learning and memory paradigms (Morris water maze, passive avoidance, novel object recognition) in normal, aged, or cognitively impaired models.

• Neurotrophic & Plasticity Research: Studying the upregulation of BDNF, TrkB, and other neurotrophins, and their downstream effects on synaptic plasticity (e.g., LTP measurement in hippocampal slices).

• Neurodegenerative Disease Models: Exploring potential benefits in models of Parkinson’s disease (e.g., MPTP/6-OHDA), Alzheimer’s disease, or retinal degeneration.

• Stress & Anxiety Research: Examining modulation of the HPA axis and behavior in stress models, though distinct from Selank’s primary anxiolytic-like profile.

• Mechanistic Studies: Serving as a tool to dissect the intracellular signaling pathways (PI3K/Akt, MAPK/ERK, CREB) activated by this peptide.

Laboratory Handling & Safety Protocol

• Storage: Store unopened lyophilized peptide vials at -20°C or below, protected from light. Methionine oxidation is a concern. Reconstituted solutions should be aliquoted, stored at -20°C, and used promptly.

• Reconstitution: Perform under sterile conditions. The peptide dissolves readily. Swirl gently.

• Laboratory Safety: Standard PPE is required. For in-vivo CNS research, strict adherence to IACUC protocols is mandatory.

• Administration Route: Note that intranasal administration (common in rodent research for direct CNS delivery) requires specific techniques and ethical considerations.

⚠️ Critical Compliance & Intended Use Disclaimer:

THIS PRODUCT IS SOLD FOR RESEARCH USE ONLY (RUO). NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

1. Intended Use: Semax is supplied as a biochemical reagent for laboratory research purposes only. It is intended for use by qualified neuroscience researchers in controlled non-human settings. The “dosing schedule” is for research models only.

2. Not for Human Consumption: Under no circumstances is this product intended for administration to humans. It is not a nootropic, cognitive enhancer, or treatment for stroke, ADHD, or any neurological condition for human use. The provided supplies are for laboratory use only.

3. Regulatory Status: This product has not been evaluated or approved by the FDA or any other health authority for any therapeutic use.

4. Regional Note: While Semax is approved as a prescription drug in Russia, THIS SPECIFIC PRODUCT IS NOT THAT DRUG and is not manufactured, packaged, or intended for human therapeutic use.

5. Researcher Responsibility: The purchaser assumes full responsibility for compliance with all laws and ethical guidelines, especially those governing animal research in neurology.