Tesamorelin 5mg

Growth Hormone-Releasing Hormone Analog for Endogenous GH Secretion Research

Tesamorelin is a synthetic, 44-amino acid peptide analog of human growth hormone-releasing hormone (GHRH) with a hexenoyl moiety added to the N-terminus to enhance stability and prolong half-life (sequence: Hexenoyl-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH₂). As a research tool, Tesamorelin acts as a potent agonist at the GHRH receptor on pituitary somatotrophs, stimulating the natural, pulsatile release of endogenous growth hormone and subsequently insulin-like growth factor 1 (IGF-1). Its modified structure makes it particularly useful for studying sustained GHRH pathway activation. Supplied as an acetate salt, this lyophilized peptide is intended strictly for controlled, non-human laboratory research investigating the physiology of the hypothalamic-pituitary axis, the specific reduction of visceral adipose tissue, and potential metabolic benefits in experimental models.

Complete Research Kit Contents & Verification

Each research order provides a complete experimental package designed for endocrine and metabolic research:

• Primary Research Compound: 10 sterile glass vials containing 5mg of lyophilized Tesamorelin Acetate peptide powder per vial.

• Reconstitution Solution: 30ml vial of sterile Bacteriostatic Water (0.9% Benzyl Alcohol), essential for creating stable peptide solutions for experimental use.

• Laboratory Administration Tools: Pack of sterile 1ml insulin syringes (29G x 1/2″) for precise measurement and transfer in accordance with research protocols.

• Sterilization Supplies: Individually wrapped alcohol prep swabs to maintain aseptic technique during vial handling and reconstitution.

• Research Protocol Documentation:

  • Dosing Schedule: Standardized administration protocol for research models focusing on chronic GHRH stimulation, visceral fat metabolism studies, and endocrine axis research.

  • Usage Instructions: Comprehensive guide covering reconstitution math, storage conditions (-20°C recommended), handling safety, and experimental design for studies requiring sustained peptide activity.

• Quality Verification: Certificate of Analysis (CoA) provided with each batch, detailing:

  • Purity Analysis (>97% by HPLC/UPLC – due to larger size)

  • Amino Acid Sequence & N-terminal Modification Verification (Mass Spectrometry)

  • Molecular Weight Confirmation (~5135 Da, varies with salt form)

  • Sterility Testing Results

  • Endotoxin Levels (<10 EU/mg)

  • Residual Solvent Analysis

  • Correct Acetylation/Hexenoylation Verification

  • Net Peptide Content

Research Applications & Scientific Utility

In a laboratory setting, Tesamorelin enables specific investigation into GHRH receptor-mediated pathways. Primary research applications include studying the selective reduction of visceral adipose tissue (VAT) without significant effects on subcutaneous fat in obesity or metabolic syndrome models, researching the restoration of a more youthful GH/IGF-1 axis profile in aging models, investigating metabolic improvements (lipid profile, insulin sensitivity) associated with increased endogenous GH pulsatility, exploring the mechanisms behind its approved clinical indication (HIV-associated lipodystrophy) in relevant experimental models, and serving as a comparator to direct GH administration or other secretagogues (like GHRPs) in studies of GH axis pharmacology.

Laboratory Handling & Safety Protocol

• Storage: Store unopened lyophilized peptide vials at -20°C or below. The larger, modified peptide benefits from consistent cold storage. Reconstituted solutions should be aliquoted and stored at -20°C and used within a defined period.

• Reconstitution: Must be performed under sterile laboratory conditions. Add bacteriostatic water gently. Due to its size, it may take slightly longer to fully dissolve. Swirl gently; do not vortex aggressively.

• Laboratory Safety: Standard personal protective equipment (PPE) including lab coat, nitrile gloves, and safety glasses must be worn.

• Pharmacokinetics: Researchers should note the extended half-life compared to native GHRH when designing injection schedules and sampling timepoints.

⚠️ Critical Compliance & Intended Use Disclaimer:

THIS PRODUCT IS SOLD FOR RESEARCH USE ONLY (RUO). NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

1. Intended Use: Tesamorelin is supplied as a biochemical reagent for laboratory research purposes only. It is intended for use by qualified researchers in controlled settings studying endocrinology and metabolism. The included “dosing schedule” refers to standardized research model administration protocols only.

2. Not for Human Consumption: Under no circumstances is this product intended for administration to humans or animals. It is not an anti-aging therapy, bodybuilding supplement, or prescription drug substitute. The provided syringes and supplies are for laboratory use only.

3. Regulatory Status: This product has not been evaluated or approved by the FDA or any other global health authority for any use. While a prescription drug version (Egrifta SV®) exists for a specific indication, THIS SPECIFIC PRODUCT IS NOT THAT DRUG.

4. Drug Comparison: This research material should not be compared to or represented as the approved drug. It is a raw peptide for investigative science.

5. Researcher Responsibility: It is the sole responsibility of the purchasing individual/institution to ensure compliance with all regulations and to use this product only for legitimate, non-human research.